THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Okazaki fragments are used to synthesize the leading strand of DNA
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The leading strand of DNA is synthesized continuously
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DNA polymerase can only synthesize DNA on the leading strand
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The lagging strand can only be synthesized once the leading strand has been completed.
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Detailed explanation-1: -The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together.
Detailed explanation-2: -During DNA replication, one new strand (the leading strand) is made as a continuous piece. The other (the lagging strand) is made in small pieces. DNA replication requires other enzymes in addition to DNA polymerase, including DNA primase, DNA helicase, DNA ligase, and topoisomerase.
Detailed explanation-3: -One strand is synthesized continuously in the direction of the replication fork; this is called the leading strand. The other strand is synthesized in a direction away from the replication fork, in short stretches of DNA known as Okazaki fragments. This strand is known as the lagging strand.
Detailed explanation-4: -The leading strand is a single DNA strand that, during DNA replication, is replicated in the 3’ – 5’ direction (same direction as the replication fork). DNA is added to the leading strand continuously, one complementary base at a time.
Detailed explanation-5: -Correct answer: The leading strand is read in the 3’-to-5’ direction away from the replication fork, while the lagging strand is read in the 3’-to-5’ direction toward the replication fork.