AP BIOLOGY

THE MOLECULAR BASIS OF INHERITANCE

DNA REPLICATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why is there a ‘leading’ strand and a ‘lagging’ strand during DNA Replication?
A
Because DNA has to get synthesized in the 5’ to 3’ direction
B
Because both strands cannot be made at the same time due to a lack of proteins
C
Because DNA has to check itself
D
Because it be like that sometimes
Explanation: 

Detailed explanation-1: -Explanation: The lagging strand exists because DNA is antiparallel and replication always occurs in the 5’ to 3’ direction.

Detailed explanation-2: -The need for accuracy probably explains why DNA replication occurs only in the 5′-to-3′ direction. If there were a DNA polymerase that added deoxyribonucleoside triphosphates in the 3′-to-5′ direction, the growing 5′-chain end, rather than the incoming mononucleotide, would carry the activating triphosphate.

Detailed explanation-3: -On the other hand, the other parent strand that runs in the 5’ to 3’ direction is not synthesized continuously but rather piece-by-piece. Therefore it is called the lagging strand because it lags ever so slightly behind the leading strand.

Detailed explanation-4: -only short DNA sequences can extend off the RNA primers DNA polymerase can assemble DNA only in the 3’ to 5’ direction it is more efficient than assembling complete new strands the replication forks block the formation of longer strands DNA polymerase can assemble DNA only in the 5’ to 3’ direction.

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