AP BIOLOGY

Detailed explanation-1: -Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine nucleotide might be inserted in place of a guanine nucleotide.

Detailed explanation-2: -A substitution is a mutation that exchanges one base for another (i.e., a change in a single “chemical letter” such as switching an A to a G).

Detailed explanation-3: -Substitution Substitution, as related to genomics, is a type of mutation in which one nucleotide is replaced by a different nucleotide. The term can also refer to the replacement of one amino acid in a protein with a different amino acid.

Detailed explanation-4: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.

Detailed explanation-5: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.