THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Inversion
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Translocation
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Substitution
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Frameshift mutation
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Detailed explanation-1: -Crohn’s disease, cystic fibrosis, and certain types of cancer are due to frameshift mutations.
Detailed explanation-2: -An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.
Detailed explanation-3: -Point Mutation: Sickle cell anemia is caused by point mutations. Frameshift Mutation: Tay-Sachs disease is caused by frameshift mutations.
Detailed explanation-4: -Deletion mutations remove one or more DNA bases. Unless they happen in multiples of 3 bases, insertions and deletions shift the reading frame-which is why they’re also called frameshift mutations. A frameshift changes the grouping of bases into codons, affecting all the amino acids downstream of the mutation.