THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Insertion-Frameshift
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Deletion-Substitution
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Deletion-Frameshift
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All of the above
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Detailed explanation-1: -Two frameshift mutations in the CFTR genes cause cystic fibrosis (one involves the insertion of two nucleotides, and the other involves the deletion of one nucleotide).
Detailed explanation-2: -Deletion. Deletion mutations are actually the cause for a large number of genetic diseases, such as two-thirds of cystic fibrosis cases and the cat cry syndrome, which is so-called because children with this syndrome often have a cry that sounds similar to a cat meowing.
Detailed explanation-3: -Crohn’s disease, cystic fibrosis, and certain types of cancer are due to frameshift mutations.
Detailed explanation-4: -Point Mutation: Sickle cell anemia is caused by point mutations. Frameshift Mutation: Tay-Sachs disease is caused by frameshift mutations.