THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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deletion at chromosome 9
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deletion at chromosome 5
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inversion at chromosome 2
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duplication at chromosome 3
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Detailed explanation-1: -Cri-du-chat (cat’s cry) syndrome, also known as 5p-(5p minus) syndrome, is a chromosomal condition that results when a piece of chromosome 5 is missing . Infants with this condition often have a high-pitched cry that sounds like that of a cat.
Detailed explanation-2: -A deletion in the short arm of chromosome 5 is an example of an unbalanced translocation, which is a chromosomal rearrangement with extra or missing genetic material. Unbalanced translocations can cause birth defects and other health problems such as those seen in cri-du-chat syndrome.
Detailed explanation-3: -Cri du chat syndrome is rare. It is caused by a missing piece of chromosome 5. Most cases are believed to occur during the development of the egg or sperm. A small number of cases occur when a parent passes a different, rearranged form of the chromosome to their child.
Detailed explanation-4: -What causes cri du chat syndrome? Cri du chat syndrome is a chromosomal disorder. A deletion of part of the short arm (the p arm) of chromosome 5 causes the condition. This deletion most often occurs randomly during the formation of reproductive cells (eggs or sperm) in early fetal development.