THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A decrease in the efficiency of cellular respiration
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An increase in the speed of nerve cells
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A change in the production of specific proteins
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A change in the cellular membranes of muscles
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Detailed explanation-1: -The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat . This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene.
Detailed explanation-2: -Who does Huntington’s disease (HD) affect? Although anyone can develop HD, it tends to run in people of European descent (having family members who came from Europe). But the main factor is whether you have a parent with HD. If you do, you have a 50% chance of also having the disease.
Detailed explanation-3: -Huntington’s disease is caused by a faulty gene that results in parts of the brain becoming gradually damaged over time. You’re usually only at risk of developing it if one of your parents has or had it. Both men and women can get it.
Detailed explanation-4: -basal ganglia-a region located at the base of the brain composed of four clusters of neurons, or nerve cells. This area is responsible for body movement and coordination. The neuron groups most prominently and consistently affected by HD-the pallidum and striatum-are located here. See neuron, pallidum, striatum.