THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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insertion
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deletion
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insertion frameshift
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substitution
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Detailed explanation-1: -The presence or absence of a gene or substantial part of a gene can be determined by hybridization, with a labelled “probe” containing the gene sequence. If the gene is present, there will be a signal; if not, there is no signal.
Detailed explanation-2: -Congenital contractural arachnodactyly (CCA) is an autosomal dominant disorder that is phenotypically similar to but genetically distinct from Marfan syndrome. Genetic-linkage analysis has implicated the fibrillin-2 gene (FBN2) as the CCA locus.
Detailed explanation-3: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.
Detailed explanation-4: -A substitution mutation changes the codon CCC to CCA, both of these codons code for Proline.