THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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retroviral insertions
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apoptosis
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missense mutations
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chromosomal translocation
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Detailed explanation-1: -The conversion of a proto-oncogene to an oncogene is called activation. Proto-oncogenes can become activated by a variety of genetic mechanisms including transduction, insertional mutagenesis, amplification, point mutations, and chromosomal translocations.
Detailed explanation-2: -However, if an error (mutation) occurs in a proto-oncogene, the gene can become turned on when isn’t supposed to be. If this happens, the proto-oncogene can turn into a malfunctioning gene called an oncogene. Cells will start to grow out of control, which leads to cancer.
Detailed explanation-3: -The mutation which cannot give rise to an oncogene? Explanation: Addition or deletion of a base producing a nonsense message and an inactive protein product cannot produce an oncogene.
Detailed explanation-4: -The activation of oncogenes involves genetic changes to cellular protooncogenes. The consequence of these genetic alterations is to confer a growth advantage to the cell. Three genetic mechanisms activate oncogenes in human neoplasms: (1) mutation, (2) gene amplification, and (3) chromosome rearrangements.