THE MOLECULAR BASIS OF INHERITANCE
RECOMBINANT DNA
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following best describes the function of ligase?
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Cutting DNA
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Repairing DNA
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Explanation:
Detailed explanation-1: -DNA ligases play an essential role in maintaining genomic integrity by joining breaks in the phosphodiester backbone of DNA that occur during replication and recombination, and as a consequence of DNA damage and its repair.
Detailed explanation-2: -Therefore, the function of DNA ligase is to form phosphodiester bonds between DNA fragments.
Detailed explanation-3: -The DNA ligase is responsible for sealing any breaks in the sugar-phosphate backbone of the strand. DNA helicase unwinds the strand. Binding proteins help keep the unwound strand open during replication. Okazaki fragments are the short sections of replicated DNA that form from the lagging strand.
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