THE MOLECULAR BASIS OF INHERITANCE
STRUCTURE OF NUCLEIC ACIDS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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to replace RNA primers with DNA during replication
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to join Okizaki fragments during replication
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to add RNA nucleotides during transcription
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to add the poly-A tail to pre-mRNA
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Detailed explanation-1: -DNA ligases are best known for their role in joining adjacent Okazaki fragments at the lagging strand of the replication fork; however, they are essentially involved in any process that requires sealing of phosphodiester bonds from the DNA backbone.
Detailed explanation-2: -DNA replication on the lagging strand produces numerous fragments called Okazaki fragments that are not joined by their sugar-phosphate backbone. The enzyme DNA ligase joins these fragments to produce a single, continuous strand of DNA.
Detailed explanation-3: -DNA ligases play an essential role in maintaining genomic integrity by joining breaks in the phosphodiester backbone of DNA that occur during replication and recombination, and as a consequence of DNA damage and its repair.
Detailed explanation-4: -Okazaki segments are joined by DNA ligase.