THE MOLECULAR BASIS OF INHERITANCE
STRUCTURE OF NUCLEIC ACIDS
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Question
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This type of substitution mutation changes a single amino acid, Sickle cell anemia is an example, This type of substitution mutation produces a change in a protein, but does not produce a frame shift mutation
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This molecule is double stranded
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This biological molecule is used to carry out our genetic code
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Detailed explanation-1: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.
Detailed explanation-2: -(MIS-sens myoo-TAY-shun) A genetic alteration in which a single base pair substitution alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense variants (or mutations) will alter the function of the protein. Also called missense variant.
Detailed explanation-3: -A missense mutation is a DNA change that results in different amino acids being encoded at a particular position in the resulting protein. Some missense mutations alter the function of the resulting protein. National Human Genome Research Institute. 38.1K subscribers.
Detailed explanation-4: -This is a type of base substitution (purine substituted by purine or pyrimidine substituted by pyrimidine) in which the change in a nucleotide in the same position results in the formation of a codon that replaces one amino acid with another amino acid.
Detailed explanation-5: -Sickle cell disease is a missense mutation. It is a type of point mutation wherein the beta-haemoglobin gene converts a GAG codon into a GUG codon. Valine is produced here in the place of glutamic acid and it causes the disease.