AP BIOLOGY

Detailed explanation-1: -The largest known gene is the human dystrophin gene, which has 79 exons spanning at least 2, 300 kilobases (kb). Transcript accumulation was monitored from four regions of the gene following induction of expression in muscle cell cultures.

Detailed explanation-2: -The largest human gene is DMD (Dystrophin).

Detailed explanation-3: -The dystrophin gene is the largest known human gene, containing 79 exons and spanning > 2, 200 kb, roughly 0.1% of the whole genome (96). The most common mutation responsible for DMD and BMD is a deletion spanning one or multiple exons.

Detailed explanation-4: -The average gene consists of 3000 bases, but size varies greatly, with the largest known human gene being dystrophin as 2.4 million bases and TDF gene as the smallest gene with 14 bases. The total number of genes was estimated at about 30, 000, which is much lower than previous estimates of 80, 000 to 1, 40, 000 genes.