AP BIOLOGY

THE MOLECULAR BASIS OF INHERITANCE

THE HUMAN GENOME

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following genetic disorders results from nondisjunction?
A
hemophilia
B
PKU
C
Sickle Cell Anemia
D
Turner’s Syndrome
Explanation: 

Detailed explanation-1: -Hence the genetic disorder caused by a nondisjunction of chromosomes during meiosis is Klinefelter Syndrome . So, the correct answer is ‘Klinefelter Syndrome’.

Detailed explanation-2: -Turner syndrome (TS) is a complex phenotype associated with complete or partial monosomy of the X chromosome, usually the result of a sporadic chromosomal nondisjunction.

Detailed explanation-3: -When this condition results from monosomy X, the chromosomal abnormality occurs as a random event during the formation of reproductive cells (eggs and sperm) in the affected person’s parent. An error in cell division called nondisjunction can result in reproductive cells with an abnormal number of chromosomes.

Detailed explanation-4: -Turner syndrome can increase the risk of an underactive thyroid (hypothyroidism) due to the autoimmune disorder Hashimoto’s thyroiditis. There is also an increased risk of diabetes. Sometimes Turner syndrome is associated with gluten intolerance (celiac disease) or inflammatory bowel disease.

Detailed explanation-5: -Turner syndrome occurs when part or all of an X chromosome is missing from most or all of the cells in a girl’s body. A girl normally receives one X chromosome from each parent. The error that leads to the missing chromosome appears to happen during the formation of the egg or sperm.

There is 1 question to complete.