THE MOLECULAR BASIS OF INHERITANCE
VIRUSES AND PRIONS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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DNA polymerase
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RNA
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PrPSc
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lysozyme
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DNA
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Detailed explanation-1: -Prion propagation requires conversion of PrPC to PrPSc, thought to occur by a template-assisted process in which PrPSc acts as a template onto which PrPC is refolded into the infectious conformation.
Detailed explanation-2: -PrPc can undergo conversion into PrPSc through spontaneous misfolding, a genetic mutation of the human PRNP gene, or exposure to a prion from an external source.
Detailed explanation-3: -Prion diseases are associated with the conversion of the alpha-helix rich prion protein (PrPC) into a beta-structure-rich insoluble conformer (PrPSc) that is thought to be infectious.
Detailed explanation-4: -PrPSc is used where evidence of proteinase resistance was demonstrated. Disease-specific PrP, or PrPd, is used where it was not possible to confirm the proteinase resistance of the PrP accumulations. Infectious prions are only used when the disease transmission was demonstrated.