THE MOLECULAR BASIS OF INHERITANCE
VIRUSES AND PRIONS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They can be inactivated by boiling at 100
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They contain a capsid.
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They are abnormal form of protein, PrP.
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They can be reliably inactivated by irradiation
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Detailed explanation-1: -Other mutations insert additional amino acids into the protein or result in an unusually short version of the protein. These changes alter the structure of PrP, leading to the production of an abnormally shaped protein, known as PrPSc, from one copy of the PRNP gene.
Detailed explanation-2: -The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform. Much less understood is how this misfolded isoform causes deadly brain illnesses.
Detailed explanation-3: -The term “prions” refers to abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins called prion proteins that are found most abundantly in the brain. The functions of these normal prion proteins are still not completely understood.
Detailed explanation-4: -Prions form abnormal aggregates of proteins called amyloids, which accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are also responsible for several other neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.