AP BIOLOGY

Detailed explanation-1: -The binding of one CO molecule to hemoglobin increases the affinity of the other binding spots for oxygen, leading to a left shift in the dissociation curve. This shift prevents oxygen unloading in peripheral tissue and therefore the oxygen concentration of the tissue is much lower than normal.

Detailed explanation-2: -Carbon monoxide binds hemoglobin, the molecule in your blood that carries oxygen. When carbon monoxide is bound to hemoglobin, oxygen cannot bind. This decreases the amount of oxygen delivered to all of your cells.

Detailed explanation-3: -Carbon monoxide in cigarette smoke binds to the hemoglobin in red blood cells, thereby reducing the oxygen-carrying capacity of the blood (Sheps et al., 1990).

Detailed explanation-4: -Carbon monoxide binds to Hb to form carboxy hemoglobin, an inactive form of hemoglobin having no oxygen carrying capacity.

Detailed explanation-5: -Carbon monoxide is known to decrease the oxygen-carrying capacity of haemoglobin.