AP BIOLOGY

BIOCHEMISTRY

ENZYMES AND METABOLISM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
As substrate concentration increases, the rate of reaction is initially reduced in ____ compared to a reaction without an inhibitor present.
A
competitive inhibition
B
non-competitive inhibition
C
both competitive and non-competitive inhibition
Explanation: 

Detailed explanation-1: -Initially, an increase in substrate concentration leads to an increase in the rate of an enzyme-catalyzed reaction. As the enzyme molecules become saturated with substrate, this increase in reaction rate levels off. The rate of an enzyme-catalyzed reaction increases with an increase in the concentration of an enzyme.

Detailed explanation-2: -Competitive inhibition can be overcome by increasing the substrate concentration. Because the inhibitor and substrate are in competition for the active site, increasing substrate concentration increases the likelihood that that substrate will bind and the reaction will progress normally.

Detailed explanation-3: -Since the inhibitor and substrate are not competing for the same binding site on the enzyme, a noncompetitive inhibitor reduces the reaction rate at all substrate concentrations.

Detailed explanation-4: -Substrate Concentration. Increasing [substrate] initially increases rate. Increasing the concentration of substrate will increase the rate of collisions, so there will be more successful collisions per second.

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