Which of the following is a reason cancer cells can evade apoptosis? (select all that apply)

CELL DIVISION AND CANCEROUS CELLS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	A mutation in the P53 gene
B	Over-expression of BAX
C	Loss of up-regulation of BAX
D	Loss of function in pro-apoptotic factors
E	Over-expression of anti-apoptotic factors

Explanation:

Detailed explanation-1: -One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell’s survival upon exposure to stressful stimuli.

Detailed explanation-2: -There are many ways in which cancer cells which evade apoptosis: caspase function can be inhibited or the trigger for apoptosis can be disabled [3]. The upregulation of antiapoptotic BCL-2 proteins and loss of BAX and/or BAK are the predominant methods of evasion.

Detailed explanation-3: -Apoptosis is the opposite of cell growth; it is cell death. To divide and grow uncontrollably, a cancer cell not only has to hijack normal cellular growth pathways, but also evade cellular death pathways. Indeed, this acquired resistance to apoptosis is characteristic of all types of cancer.

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