CELL RESPIRATION
STRUCTURE OF THE MITOCHONDRION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cristae
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matrix
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inner membrane
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outer membrane
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Detailed explanation-1: -Pyruvate crosses the outer mitochondrial membrane (OMM) probably via the VDAC into the intermembrane space (IMS). Pyruvate is then transported across the IMM by the MPC.
Detailed explanation-2: -Transport of pyruvate across the outer mitochondrial membrane is by passive diffusion through the large nonselective voltage-dependent anion channel (VDAC) (1, 2).
Detailed explanation-3: -Pyruvate synthesized in the cytoplasm of yeast is transported into the mitochondrial matrix, a process mediated by the Yil006w transporter that is present in the inner mitochondrial membrane17.
Detailed explanation-4: -The transport of pyruvate into mitochondria depends on the proton-motive force across the inner mitochondrial membrane.
Detailed explanation-5: -Pyruvate, also called pyruvic acid, is a polar molecule with a negative charge. Charged polar molecules are unable to pass through the phospholipid bilayer due to the large span of non-polar fatty acid tails in the middle. Therefore these types of molecules require a transport protein to cross a cell membrane.