AP BIOLOGY

Detailed explanation-1: -Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.

Detailed explanation-2: -A deletion changes the DNA sequence by removing at least one nucleotide in a gene. Small deletions remove one or a few nucleotides within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the affected protein or proteins.

Detailed explanation-3: -No; only a small percentage of variants cause genetic disorders-most have no impact on health or development. For example, some variants alter a gene’s DNA sequence but do not change the function of the protein made from the gene.

Detailed explanation-4: -If the segments of DNA that are exchanged are not the same size, large sections may experience a deletion mutation, as seen below. A deletion mutation can be a serious mutation, or a harmless mutation.