AP BIOLOGY

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HEREDITY

MUTATIONS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Suppose a gene has the DNA nucleotide sequence1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17C T G G C A T G C T T C G G A A A(No real gene could be this short, but for our purposes, this will suffice.) Which one of the following mutations would probably produce the greatest change in the activity of the protein for which this gene codes?
A
substitution of A for G in position 3
B
deletion of the C at position 5
C
deletion of the A at position 15
D
addition of G between position 14 and 15
E
substitution of A for T at position at 11
Explanation: 

Detailed explanation-1: -Each end of DNA molecule has a number. One end is referred to as 5’ (five prime) and the other end is referred to as 3’ (three prime). The 5’ and 3’ designations refer to the number of carbon atom in a deoxyribose sugar molecule to which a phosphate group bonds.

Detailed explanation-2: -The mRNA message is translated in segments of three adjacent nucleotides called a codon. Each codon is translated into 1 of 20 amino acids (eFig. 62.4). A total of 64 different codons can be generated from the 4 bases found in RNA.

Detailed explanation-3: -To find the gene coding sequence, look at the Genomic regions, transcripts, and products section or the NCBI Reference Sequences (RefSeq) section of the Gene record: Clicking on the GenBank link displays the GenBank record in the Nucleotide database.

There is 1 question to complete.
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