AP BIOLOGY

Detailed explanation-1: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.

Detailed explanation-2: -A point mutation is where you change one base in the DNA to another. A missense mutation occurs when that point mutation causes a different amino acid to be placed from that codon. Because multiple codons code for the same amino acid, not all point mutations will cause a missense mutation.

Detailed explanation-3: -A substitution is a mutation that exchanges one base for another (i.e., a change in a single “chemical letter” such as switching an A to a G). Such a substitution could: change a codon to one that encodes a different amino acid and cause a small change in the protein produced.

Detailed explanation-4: -Single base substitutions are called point mutations, recall the point mutation Glu—–> Val which causes sickle-cell disease.

Detailed explanation-5: -Point Mutation A point mutation occurs in a genome when a single base pair is added, deleted or changed. While most point mutations are benign, they can also have various functional consequences, including changes in gene expression or alterations in encoded proteins.