AP BIOLOGY

Detailed explanation-1: -Frameshift mutations are among the most deleterious changes to the coding sequence of a protein. They are extremely likely to lead to large-scale changes to polypeptide length and chemical composition, resulting in a non-functional protein that often disrupts the biochemical processes of a cell.

Detailed explanation-2: -Why is a frameshift mutation at the beginning of a gene sequence more damaging than one at the end of a sequence? Changes more of actual sequence of amino acid.

Detailed explanation-3: -1 Answer. Frameshift mutations completely alter the entire protein sequence that occurs after the mutation, whereas a substitution only alters a single amino acid.

Detailed explanation-4: -An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.