AP BIOLOGY

Detailed explanation-1: -The gene with the instructions for making factor is found only on the sex chromosome labeled X. If the gene is faulty, the result is hemophilia unless there is a dominant, normal gene on a matching X chromosome. Hemophilia is a sex-linked recessive disorder. These kinds of defects occur more often in men than in women.

Detailed explanation-2: -Although it is rarer for women to have hemophilia when compared to men, women can also have the condition. It is important to raise awareness about this fact to help women with hemophilia receive the care and support they need to live healthy lives.

Detailed explanation-3: -The condition primarily affects males. The complications of hemophilia can be severe, and treatment is often expensive. It is important to know how many people in the United States have hemophilia.

Detailed explanation-4: -A total of 23, 196 males (98%) and 1, 667 females (48%) met a diagnosis for severe, moderate, or mild hemophilia. Hemophilia was classified as severe if clotting factor activity level was less than 1% of normal; moderate if it was 1%–5% of normal; and mild if it was 5%–40% of normal.

Detailed explanation-5: -This means that males only have one copy of most of the genes on the X chromosome, whereas females have 2 copies. Thus, males can have a disease like hemophilia if they inherit an affected X chromosome that has a mutation in either the factor VIII or factor IX gene.