LABORATORY REVIEW
CELL RESPIRATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Fewer ATP would be generated because the proton gradient is lost
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Fewer ATP would be generated because protons can’t diffuse through ATP synthase
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Even more ATP can be made through susbstrate level phosphorylation
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More ATP could be generated as electrons donate their energy directly to ADP and Phosphate.
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Detailed explanation-1: -Inhibition of the ATP synthase compromises the output of ATP by OXPHOS and rewires energy metabolism to an enhanced glycolysis.
Detailed explanation-2: -The H+-ATP Synthase is Downregulated in Cancer The H+-ATP synthase consumes the proton electrochemical gradient generated across the inner mitochondrial membrane by the electron transport chain to drive ATP synthesis (17, 18).
Detailed explanation-3: -C) Oligomycin blocks the proton transfer through F0 of ATP synthase and therefore blocks the phosphorylation of ADP to form ATP.
Detailed explanation-4: -The proton gradient produced by proton pumping during the electron transport chain is used to synthesize ATP. Protons flow down their concentration gradient into the matrix through the membrane protein ATP synthase, causing it to spin (like a water wheel) and catalyze conversion of ADP to ATP.