. In GPCR signaling, the G protein Inactive alpha subunit gives up associated cAMP and takes up GDP, conformation changes again, released from beta/gamma subunits and interacts with target proteins.

MOLECULAR BIOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	True
B	False

Explanation:

Detailed explanation-1: -The main physiological functions of G-proteins are to relay the signals from GPCRs which function as GEFs for G-proteins. Binding with exogenous or endogenous agonists induces GPCRs into an active conformational state which, in turn, influences intracellular binding of G-proteins or arrestin proteins [23, 24].

Detailed explanation-2: -G proteins remain active as long as their alpha subunits are joined with GTP. However, when this GTP is hydrolyzed back to GDP, the subunits once again assume the form of an inactive heterotrimer, and the entire G protein reassociates with the now-inactive GPCR.

Detailed explanation-3: -Gs suppresses SHH signal transduction through different cellular mechanisms. In the canonical signaling pathway, Gs activation stimulates adenylyl cyclase activity to produce cAMP, which in turn activates the cAMP-dependent PKA.

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AP BIOLOGY

LABORATORY REVIEW

MOLECULAR BIOLOGY