LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Sickle Cell AnemiaSequence for Normal HemoglobinDNA Sequence ATGGTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACTAmino Acid Seq.STARTValHisLeuThrProGluGluLysSerAlaValThe Sequence for Sickle Cell HemoglobinDNA Sequence ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT GCC GTT ACTAmino Acid Seq.STARTValHisLeuThrProValGluLysSerAlaValWhat mRNA would be transcribed from the normal hemoglobin DNA?
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TAC CAC GTG GAC TGA GGA CAC CTC TTC AGA CGG CAA TGA
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UAC CAC GUC GAC UGA GGA CUC CUC UUC AGA CGG CAA UGA
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UAC CAC GUG GAC UGA GGA CAC CUC UUC AGA CGG CAA UGA
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TAC CAC GTC GAC TGA GGA CTC CUC TTC AGA CGG CAA TGA
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Explanation:
Detailed explanation-1: -The specific base sequence for these amino acids is: GTG/CAC/CTG/ACT/CCT/GAG. Sickle cell hemoglobin (Hemoglobin S) results when, glutamic acid that is normally present in the sixth position on the beta globin chain is substituted with valine.
Detailed explanation-2: -So, the correct option is ‘Val, His, Leu, Thr, Pro, Val, Glu’. Was this answer helpful?
Detailed explanation-3: -The chain of colored boxes represent the first eight amino acids in the beta chain of hemoglobin. The sixth position in the normal beta chain has glutamic acid, while sickle beta chain has valine. This is the sole difference between the two.
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