LABORATORY REVIEW
MOLECULAR BIOLOGY
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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frameshift mutation
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point mutation
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reading frame mutation
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all of these are correct
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Detailed explanation-1: -Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine nucleotide might be inserted in place of a guanine nucleotide.
Detailed explanation-2: -Substitution, as related to genomics, is a type of mutation in which one nucleotide is replaced by a different nucleotide. The term can also refer to the replacement of one amino acid in a protein with a different amino acid.
Detailed explanation-3: -Types of Point Mutations. We are going to focus on the following point mutations: frameshift, silent, nonsense, and missense. Let’s start with a frameshift mutation, where there’s an insertion or deletion of one or more bases.
Detailed explanation-4: -An example of point mutation is sickle cell anaemia. It involves mutation in a single base pair in the beta-globin chain of haemoglobin pigment of the blood.
Detailed explanation-5: -There are three types of DNA Mutations: base substitutions, deletions and insertions.