AP BIOLOGY

Detailed explanation-1: -The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins.

Detailed explanation-2: -OTHER USES OF SCOP The clustering of sequences of protein chains of known structures at different levels of sequence similarity gives a series of non-redundant sequence databases known as PDB40, PDB90, PDB95 etc.

Detailed explanation-3: -The Protein Data Bank (PDB) was established in 1971 as the central archive of all experimentally determined protein structure data. Today the PDB is maintained by an international consortia collectively known as the Worldwide Protein Data Bank (wwPDB).

Detailed explanation-4: -SCOP and CATH are hierarchical domain classification systems. Domains within the same SCOP superfamily have structural and functional similarities that suggest a common evolutionary origin but may not share a detect-able sequence similarity. The equivalent CATH category is the ‘’Homologous Superfamily” (H-level).

Detailed explanation-5: -The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. The SCOP hierarchy comprises the following levels: Species, Protein, Family, Superfamily, Fold and Class.