AP BIOLOGY

Detailed explanation-1: -The Lock and Key model explains that the enzyme needs to bind substrate, but once the reaction progresses to the transition state and product formation, the active site would not be able to accommodate this change.

Detailed explanation-2: -A Lock and Key analogy may be used to describe the fundamental action of a single substrate enzyme. In this case, the enzyme is the lock, and the substrate is the key. Only the correct size key, which is the substrate, enters the keyhole, which is the active site of the lock, which is the enzyme.

Detailed explanation-3: -The active site of enzyme is highly specific for its substrate. The enzyme and substrate fit like a lock and key and thus is a lock and key model of enzyme action.

Detailed explanation-4: -Enzymes Sites Are Keyholes Each enzyme has receptor sites that allow specific substrates to enter and create a chemical reaction product. The enzyme sites work like the keyhole in a lock. Like the lock on a door, only certain keys will fit in the keyholes, and perhaps only one key will open the lock.