AP BIOLOGY

LABORATORY REVIEW

MOLECULAR BIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence?
A
splicing
B
frameshift
C
elongation
D
mutagen
Explanation: 

Detailed explanation-1: -A frameshift mutation in a gene refers to the insertion or deletion of nucleotide bases in numbers that are not multiples of three. This is important because a cell reads a gene’s code in groups of three bases when making a protein.

Detailed explanation-2: -Frameshift mutations Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.

Detailed explanation-3: -4.4 Frameshift Mutations. Frameshift mutations are deletions or additions of 1, 2, or 4 nucleotides that change the ribosome reading frame and cause premature termination of translation at a new nonsense or chain termination codon (TAA, TAG, and TGA).

Detailed explanation-4: -Frameshift mutation: This type of mutation occurs when the addition or loss of DNA bases changes a gene’s reading frame. A reading frame consists of groups of 3 bases that each code for one amino acid. A frameshift mutation shifts the grouping of these bases and changes the code for amino acids.

Detailed explanation-5: -Listen to pronunciation. (FRAYM-shift myoo-TAY-shun) An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.

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