THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The receptor will allow Ligand A to enter via facilitated diffusion into the cytoplasm.
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Ligand A will enter the nucleus and attach itself to the DNA.
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The receptor will undergo a conformational change that will lead to the next step in the transduction pathway.
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Proteins cannot serve as ligands, so this scenario is not plausible.
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Detailed explanation-1: -When a ligand binds to a protein, it undergoes a conformational change which in turn leads to a physiological response. The time a ligand spends attached to a receptor or specific protein is a function of the affinity between the ligand and the protein.
Detailed explanation-2: -Ion Channel Receptors When a ligand binds an ion channel receptor, a channel through the plasma membrane opens that allows specific ions to pass through. This process requires a specialized membrane-spanning region of the receptor.
Detailed explanation-3: -What is the next step in receptor tyrosine kinase signaling after the ligand binds to the receptor? Explanation: After a ligand binds to receptor tyrosine kinases, the receptors need to form a dimer to foster activation of their tyrosine kinase activity.
Detailed explanation-4: -When the ligand binds to the internal receptor, a conformational change is triggered that exposes a DNA-binding site on the protein. The ligand-receptor complex moves into the nucleus, then binds to specific regulatory regions of the chromosomal DNA and promotes the initiation of transcription (Figure 4).