AP BIOLOGY

Detailed explanation-1: -Autocrine signaling also plays a vital role in cellular homeostasis. For example, progesterone has been found to act as an autocrine signal in breast cancer. Cell signaling is the form of communication between cells. Cells communicate with each other through several cell signaling pathways.

Detailed explanation-2: -Autocrine signaling loops with positive or negative feedback are an important feature in cancer, where they enable context-dependent cell signaling in the regulation of growth, survival, and cell motility.

Detailed explanation-3: -Wnt/-catenin signaling Dysregulated Wnt signaling is linked to numerous cancers including; leukemia, melanoma, breast and gastrointestinal cancers.

Detailed explanation-4: -An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.