AP BIOLOGY

Detailed explanation-1: -Inflammatory mediators are molecules produced by activated cells that intensify and prolong the inflammatory response. Histamine is a potent inflammatory mediator, commonly associated with allergic reactions, promoting vascular and tissue changes and possessing high chemoattractant activity.

Detailed explanation-2: -The inflammatory response (inflammation) occurs when tissues are injured by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals including histamine, bradykinin, and prostaglandins. These chemicals cause blood vessels to leak fluid into the tissues, causing swelling.

Detailed explanation-3: -Histamine contributes to the progression of allergic-inflammatory responses by enhancement of the secretion of pro-inflammatory cytokines, such as IL-1, IL-1, and IL-6, as well as chemokines like RANTES or IL-8, both in several cell types and in local tissues (Fig 1).

Detailed explanation-4: -Histamine is the most important mediator released from the mast cell involved with an allergic response. Histamine is derived from the amino acid histidine and works through three different receptors (H1, H2, H3). Stimulation of H1 receptors by the binding of histamine induces the classic allergic reaction.