THE HUMAN IMMUNE SYSTEM
BLOOD GROUPS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They will destroy Kell antigens
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They destroy Kell antibodies
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They will enhance Kell antigens
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They will enhance disulfide bonds
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Detailed explanation-1: -DTT destroys not only CD38, but also other antigens. Most importantly, antigens of the Kell blood group system are destroyed, making the screen insensitive for anti-K, anti-k, anti-Kpa, anti-Jsa, anti-Kpb and anti-Jsb 5.
Detailed explanation-2: -DTT treatment can be used to disperse spontaneous agglutination of RBCs caused by heavy IgM autoantibody coating that invalidates ABO/Rh cell grouping and direct antiglobulin tests.
Detailed explanation-3: -ZZAP treatment destroys all antigens in the Kell, Landsteiner-Wiener, Cartwright, Dombrock, and Knops blood group systems as well as antigens destroyed by proteases (e.g., M, N, S, Fya, and Fyb).
Detailed explanation-4: -DTT is used to differentiate between IgM and IgG antibodies by inactivating IgM antibodies allowing identification of any unaffected IgG antibody. DTT treatment of test serum, plasma or eluate can aid in antibody investigation where there may be a mixture of IgM and IgG antibodies.