THE HUMAN IMMUNE SYSTEM
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Fibrin is converted to fibrinogen which then altersprothrombin into thrombin.
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Thrombin is converted to prothrombin which then altersfibrinogen into fibrin.
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Fibrinogen is converted to fibrin which then altersprothrombin into thrombin.
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Prothrombin is converted to thrombin which then altersfibrinogen into fibrin.
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Detailed explanation-1: -Once activated to factor Xa, it goes on to activate factor II (prothrombin) into factor IIa (thrombin). Also, factor Xa requires factor V as a cofactor to cleave prothrombin into thrombin. Factor IIa (thrombin) goes on to activate fibrinogen into fibrin.
Detailed explanation-2: -The mechanism of hemostasis can divide into four stages. 1) Constriction of the blood vessel. 2) Formation of a temporary “platelet plug.” 3) Activation of the coagulation cascade. 4) Formation of “fibrin plug” or the final clot.
Detailed explanation-3: -Thrombin is produced by proteolytic activation of the precursor, prothrombin, in the first committed step of the pathway to thrombus formation. Thrombin catalyses thrombus formation and also a series of reactions that both positively and negatively regulate flux through the coagulation cascade.
Detailed explanation-4: -The coagulation process consists of the conversion of prothrombin to thrombin and of the subsequent action of thrombin on fibrinogen to produce fibrin. In the fibrinogen-fibrin conversion fibrinogen, already a high polymer of many amino acids is converted to an even higher polymeric form or coagulum, the fibrin clot.
Detailed explanation-5: -Blood coagulation occurs in the following sequence: Whenever there is rupture of blood vessels or damage is caused to blood, a complex of substances called prothrombin activator complex is formed. The activators convert prothrombin into thrombin. Thrombin acts as an enzyme and converts fibrinogen into fibrin threads.