AP BIOLOGY

Detailed explanation-1: -Acute HTRs: These are due to preformed antibodies against donor RBC antigens present in the recipient’s blood. ABO incompatibility reactions are the most dreaded hemolytic transfusion reactions due to their ability to cause intravascular hemolysis.

Detailed explanation-2: -That means people with type A blood create antibodies against B antigens. A person with type A blood receiving a transfusion of type B or AB blood would have an ABO incompatibility reaction. In an ABO incompatibility reaction, your immune system attacks the new blood cells and destroys them.

Detailed explanation-3: -Hemolysis is considered the strongest positive reaction that can occur and indicates the presence of a potent, complement-fixing antibody, but it is not commonly seen. The RBC agglutination is most commonly seen as a sign of a positive reaction in transfusion medicine tests.

Detailed explanation-4: -Hemolytic transfusion reactions (HTRs) are reactions in which donor RBCs are destroyed by antibodies in the recipient’s circulation. They occur when antigen-positive donor RBCs are transfused into a patient who has preformed antibodies to that antigen.