AP BIOLOGY

Detailed explanation-1: -There is, however, evidence that IgG, purposefully in high abundance in IVIG products, can induce intravascular hemolysis. If IgM is bound to a RBC in the circulation, the complement cascade may become activated and punctures the membrane, causing intravascular hemolysis.

Detailed explanation-2: -Acute hemolytic transfusion reactions (AHTR) are most commonly the result of antibodies in the recipient’s plasma that aredirected against antigens on the donor RBCs. ABO incompatibility due to clerical error is the most frequent cause.

Detailed explanation-3: -Intravascular hemolysis is hemolysis produced when the antibody to the red blood cell (RBC) antigen binds and causes complement activation.

Detailed explanation-4: -A hemolytic transfusion reaction is a serious complication that can occur after a blood transfusion. The reaction occurs when the red blood cells that were given during the transfusion are destroyed by the person’s immune system. When red blood cells are destroyed, the process is called hemolysis.