THE HUMAN IMMUNE SYSTEM
TRANSFUSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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IF sang <0
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pic Edp indosable
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normal blood light chain ratio
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myelogram: plasmacytosis <10% and MRD cytometry <0
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Detailed explanation-1: -The necessary criterion to make the diagnosis of LCDD requires that all tissues to be stained for kappa and light chains and the tissue must exhibit kappa fixation along the tubular basement membrane. The tubular deposits are present predominantly along the loops of Henle, distal tubules, and proximal tubules.
Detailed explanation-2: -The diagnosis of MM is established when at least 10% clonal plasma cells are present in the bone marrow or a biopsy-proven plasmacytoma is found, and at least one myeloma-defining event is present.
Detailed explanation-3: -The normal ranges for free light chains are generally: 3.3 to 19.4 milligrams per liter (mg/L) kappa free light chains. 5.71 to 26.3 mg/L lambda free light chains. 0.26 to 1.65 ratio of kappa/lambda.
Detailed explanation-4: -We conclude that a high FLC ratio ≥ 100 is a predictor of imminent progression in SMM, and such patients may be considered candidates for early treatment intervention.