THE HUMAN IMMUNE SYSTEM
TRANSFUSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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t(9;22) BCR-ABL
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t(8;22) BCR-ABL
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t(8;22) t(8;14)Myc
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t(4, 11) MLL
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Detailed explanation-1: -DNMT3A and RUNX1 mutations represent the most important predictors of shorter overall survival in AML patients aged less than 60 years and particularly in those with intermediate-risk cytogenetic.
Detailed explanation-2: -The most frequent abnormality among adults with ALL is the Philadelphia chromosome (Ph), i.e., t(9; 22)(q34; q11. 2)/BCR-ABL1, which is detected in 11–29% of patients [8, 11–15]. In contrast, t(9; 22) is relatively rare in children (1–3%) [9, 31, 44].
Detailed explanation-3: -The t(4; 11)(q21; q23) has been associated with marked lineage heterogeneity. Most of the reported cases were classified as acute lymphoblastic leukemia (ALL). The t(4; 11) is one of the commonest specific chromosomal translocations in ALL, occurring in 2% of childhood and 5% of adult cases.
Detailed explanation-4: -Definition. An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material. [ from NCI]