THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Okazaki fragments are used to synthesize the leading strand of DNA.
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The leading strand of DNA is synthesized continuously.
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DNA polymerase can only synthesize DNA on the leading strand.
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The lagging strand can only be synthesized once the leading strand has been completed.
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Detailed explanation-1: -Correct answer: The leading strand is read in the 3’-to-5’ direction away from the replication fork, while the lagging strand is read in the 3’-to-5’ direction toward the replication fork.
Detailed explanation-2: -The leading strand is synthesized by adding nucleotides to the 3’ end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5’ end. The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together.
Detailed explanation-3: -The leading strand is synthesized in the same direction as the movement of the replication fork, and the lagging strand is synthesized in the opposite direction.
Detailed explanation-4: -The lagging strand is a single DNA strand that, during DNA replication, is replicated in the 5′ – 3′ direction (opposite direction to the replication fork). DNA is added to the lagging strand in discontinuous chunks called ‘okazaki fragments’.