THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Involves the addition or deletion of one or more nucleotides
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Results in a new codon sequence
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Results in a new amino acid sequence
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All of the above
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Detailed explanation-1: -A frameshift mutation in a gene refers to the insertion or deletion of nucleotide bases in numbers that are not multiples of three. This is important because a cell reads a gene’s code in groups of three bases when making a protein.
Detailed explanation-2: -Listen to pronunciation. (FRAYM-shift myoo-TAY-shun) An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.
Detailed explanation-3: -Insertions, deletions, and duplications can all be frameshift variants. Some regions of DNA contain short sequences of nucleotides that are repeated a number of times in a row.
Detailed explanation-4: -A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read. A DNA sequence is a chain of many smaller molecules called nucleotides.
Detailed explanation-5: -Two frameshift mutations in the CFTR genes cause cystic fibrosis (one involves the insertion of two nucleotides, and the other involves the deletion of one nucleotide).