THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Identify the Frameshift Deletion mutation from the following DNA sequence:ATG CCA AAT
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ATG TCA AAT
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ATG CCT AAA T
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ATC CA AT
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ATG CCA AAT
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Explanation:
Detailed explanation-1: -Frameshift mutations in microsatellites can be identified by extraction of DNA from both normal and tumor tissue (usually paraffin-embedded tissue), amplification of selected microsatellites by PCR, and analysis of fragment size by gel electrophoresis or an automated sequencer (Fig.
Detailed explanation-2: -Two frameshift mutations in the CFTR genes cause cystic fibrosis (one involves the insertion of two nucleotides, and the other involves the deletion of one nucleotide).
Detailed explanation-3: -A substitution mutation changes the codon CCC to CCA, both of these codons code for Proline.
Detailed explanation-4: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.
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