AP BIOLOGY

Detailed explanation-1: -One well known example of an inversion mutation in humans is hemophilia, a disease that inhibits the ability of blood to clot. Researchers discovered the gene responsible for hemophilia years ago, but also found that DNA from a person with hemophilia had the same genetic makeup as a person without the disease.

Detailed explanation-2: -Inversions are a special type of mutation in which a piece of chromosomal DNA is flipped 180 degrees. For an inversion to occur, two breaks occur in a chromosome, the region between the breaks gets inverted, and the ends of the region get rejoined to the rest of the chromosome.

Detailed explanation-3: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.

Detailed explanation-4: -The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat . This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene.