THE MOLECULAR BASIS OF INHERITANCE
GENE MUTATION
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Silent mutation
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Nonsense mutation
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Missense mutation
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Frameshift mutation
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Detailed explanation-1: -Which of the following is not a point mutation? Explanation: Point mutation concerns a single base. Thus substitution, which includes transversion, and insertion or deletion, falls within point mutation. On the other hand, translocation involves a stretch of bases so it is not a point mutation.
Detailed explanation-2: -A frameshift mutation is an insertion or deletion of a nucleotide base that changes the reading frame. A point mutation does not change the frame and only changes one amino acids.
Detailed explanation-3: -No, point mutations and frameshift mutations are two different types of gene mutations that happen in the nucleotide sequence of a gene.
Detailed explanation-4: -Crohn’s disease, cystic fibrosis, and certain types of cancer are due to frameshift mutations.
Detailed explanation-5: -Types of Point Mutations. We are going to focus on the following point mutations: frameshift, silent, nonsense, and missense. Let’s start with a frameshift mutation, where there’s an insertion or deletion of one or more bases.