THE MOLECULAR BASIS OF INHERITANCE
RECOMBINANT DNA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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the entire genome of the organism
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a section of DNA (a gene) that codes for a protein
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a protein that can be used to treat a disease
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a protein that has an interesting shape
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Detailed explanation-1: -Therapeutic proteins are extensively used in the treatment of cancer, HIV, and other diseases. Monoclonal antibodies, IFNs, and cytokines are examples of some of the macromolecular therapeutic proteins.
Detailed explanation-2: -The first recombinant protein used in treatment was recombinant human insulin in 1982 and the RP industry has rapidly grown since. To date, more than 130 RPs have been approved by the US FDA for clinical use. However, more than 170 RPs are produced and used in medicine worldwide.
Detailed explanation-3: -Due to their central role in biological function, protein interactions also control the mechanisms leading to healthy and diseased states in organisms. Diseases are often caused by mutations affecting the binding interface or leading to biochemically dysfunctional allosteric changes in proteins.
Detailed explanation-4: -Protein misfolding is believed to be the primary cause of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Creutzfeldt-Jakob disease, cystic fibrosis, Gaucher’s disease and many other degenerative and neurodegenerative disorders.