AP BIOLOGY

Detailed explanation-1: -Once these crucial Cell Cycle genes start behaving abnormally, cancer cells start to proliferate wildly by repeated, uncontrolled mitosis.

Detailed explanation-2: -Mitosis: Anaphase Also lines our hollow or tube-like organs/tissues such as the digestive tract. Since these tissues are often exposed to environmental insults such as chemicals and solar radiation and are often divide rapidly to replace lost cells, many cancers arise in epithelial tissues.

Detailed explanation-3: -Mitosis occurs infinitely. The cells never die in cancer, as cancer cells can utilize telomerase to add many telomeric sections to the ends of DNA during DNA replication, allowing the cells to live much longer than other somatic cells. [3] With this mechanism, cancer cells that usually die simply continue to divide.

Detailed explanation-4: -We found that, the expression of these proteins is increased during the mitosis stage of cell division. Therefore the blockade of cell cycle in the mitotic phase may results in increased immune resistance that can further help the cancer cells in evading immune attack.