THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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the chromosomes would segregate but in a disorderly pattern
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The chromosomes would coil and shorten but have no spindle to which to attach
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The cells would immediately die
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The cells would be unable to begin M and stay in G2
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Detailed explanation-1: -Which of the following would result if colchicine is added to a sample of cells in G2? The chromosomes would coil and shorten but have no spindle to which to attach.
Detailed explanation-2: -Colchicine which prevents spindle formation is chemically an alkaloid. Colchicine is a mitotic inhibitor. A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules and prevents spindle formation.
Detailed explanation-3: -Colchicine, the classic antimitotic poison, disrupts cell division by preventing proper assembly of microtubules in the mitotic spindle. Colchicine is known to act by binding to tubulin, the heterodimeric subunit of microtubules.
Detailed explanation-4: -Colchicine is a classical anti-mitotic drug which blocks mitotic cells in metaphase. It binds to soluble tubulin to form tubulin-colchicine complexes in a poorly reversible manner, which then binds to the ends of microtubules to prevent the elongation of the microtubule polymer.