THE HUMAN IMMUNE SYSTEM
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Disulfide bonds
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Polypeptide bonds
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Dihydrogen bonds
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Monosulfide bonds
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Detailed explanation-1: -Each IgG contains a total of 12 intra-chain disulfide bonds; each disulfide bond is associated with an individual IgG domain. The two heavy chains are connected in the hinge region by a variable number of disulfide bonds: 2 for IgG1 and IgG4, 4 for IgG2 and 11 for IgG3.
Detailed explanation-2: -Hair proteins are held together by disulfide bonds, from the amino acid cysteine.
Detailed explanation-3: -Disulfide bonds function to stabilize the tertiary and/or quaternary structures of proteins and may be intra-protein (i.e., stabilizing the folding of a single polypeptide chain) or inter-protein (i.e., multi-subunit proteins such as antibodies or the A and B chains of insulin).
Detailed explanation-4: -Antibodies have evolved to function in oxidative, extracellular environments. A pair of cysteines in close proximity will oxidatively react to form a disulfide bond that fixes and stabilizes the tertiary structure of a protein.